Key result
Male gender, older age at diagnosis, black race, and radiotherapy were associated with a higher likelihood of cardiac death among cancer survivors >5 years (P<0.0001).
Why the study?
What is the risk and frequency of cardiac death among long-term (>5 years) cancer survivors?
Observational
Yes
What is the risk and frequency of cardiac death among long-term (>5 years) cancer survivors?
p-value: p=<0.0001
Cardiac death is a significant cause of mortality among long-term cancer survivors, highlighting the need for cardiovascular risk management in this population.
May support cardiac risk stratification in long-term cancer survivors; leaves open whether targeted interventions improve survival.
BACKGROUND: Population-based data on the risk of cardiac death among cancer survivors are needed. This scenario was evaluated in cancer survivors (>5 years) registered within the Surveillance, Epidemiology and End Results (SEER) database. METHODS: The SEER database was queried using SEER*Stat to determine the frequency of cardiac death compared to other causes of death; and to determine heart disease-specific and cancer-specific survival rates in survivors of each of the 10 most common cancers in men and women in the SEER database. RESULTS: For cancer-specific survival rate, the highest rates were related to thyroid cancer survivors; while the lowest rates were related to lung cancer survivors. For heart disease-specific survival rate, the highest rates were related to thyroid cancer survivors; while the lowest rates were related to both lung cancer survivors and urinary bladder cancer survivors. The following factors were associated with a higher likelihood of cardiac death: male gender, old age at diagnosis, black race and local treatment with radiotherapy rather than surgery (P < 0.0001 for all parameters). CONCLUSION: Among cancer survivors (>5 years), cardiac death is a significant cause of death and there is a wide variability among different cancers in the relative importance of cardiac death vs. cancer-related death.
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Omar Abdel‐Rahman (2017) conducted an observational in Cancer survivors. Cancer survivorship and associated risk factors was evaluated on Frequency of cardiac death and heart disease-specific survival rates (p=<0.0001). Male gender, older age at diagnosis, black race, and radiotherapy were associated with a higher likelihood of cardiac death among cancer survivors >5 years (P<0.0001).
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