Reperfusion hemorrhage independently predicted poor 90-day outcomes in acute ischemic stroke patients following successful thrombectomy (OR 3.3; 95% CI 1.67-5; P=0.001).
RCT (n=70)
Reperfusion hemorrhage, older age, higher NIHSS, and increased time from imaging to arterial puncture independently predict poor outcomes in acute ischemic stroke patients despite successful thrombectomy.
Odds Ratio: 3.3 (95% CI 1.67–5)
valor p: p=0.001
Background Thrombectomy for acute ischemic stroke treatment leads to improved outcomes, but many patients do not achieve a good outcome despite successful reperfusion. We determined predictors of poor outcome after successful thrombectomy (TICI 2b–3) with an emphasis on modifiable factors. Methods Patients from the randomized DEFUSE 3 trial who underwent thrombectomy with TICI 2b–3 revascularization were included. Primary outcome was a poor outcome at 90 days (modified Rankin Scale score 3–6). Results 70 patients were included. Poor outcome patients were older (73.5 vs 66.5 years; P=0.01), more likely to be female (68% vs 39%; P=0.02), had higher NIHSS scores (20 vs 13; PConclusions In late time windows, both mild and severe reperfusion hemorrhage were associated with poor outcomes. Older age, higher NIHSS, and increased time from imaging to arterial puncture were also associated with poor outcomes despite successful revascularization. Trial registration https://clinicaltrials.gov/ct2/show/NCT02586415
Rees et al. (Sat,) conducted a rct in Acute ischemic stroke (n=70). Reperfusion hemorrhage vs. No reperfusion hemorrhage was evaluated on Poor outcome at 90 days (modified Rankin Scale score 3-6) (OR 3.3, 95% CI 1.67-5, p=0.001). Reperfusion hemorrhage independently predicted poor 90-day outcomes in acute ischemic stroke patients following successful thrombectomy (OR 3.3; 95% CI 1.67-5; P=0.001).
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