Cardiac CT detected significantly fewer LAA-ostium thrombi compared to thrombi located within the LAA (48.3% vs 89.3%; p=0.001), with false negatives more common in smaller, high-flow ostium thrombi.
Case-Control (n=726)
No
Does Cardiac CT accurately detect LAA thrombus compared to TEE in patients undergoing catheter ablation for atrial fibrillation?
Cardiac CT with a 30-second delay is less sensitive than TEE for detecting LAA thrombi, particularly small thrombi located at the LAA ostium with higher flow velocities.
Tasa de eventos absoluta: 48.3% vs 89.3%
valor p: p=0.001
OBJECTIVE: Cardiac CT (CCT) is an emerging non-invasive modality for assessing left atrial appendage (LAA) thrombus, but the results were conflicting. Our study aims to evaluate the accuracy of CCT for detecting LAA thrombus in patients undergoing catheter ablation of atrial fibrillation, using trans-oesophageal echocardiography (TEE) as the reference standard. DESIGN: Case-control study. SETTING: Patient data were collected from a tertiary hospital in China between 2017 and 2022. PARTICIPANTS: The study enrolled 726 patients (male: 60.2%, age: 61±11 years) who had both TEE and CCT before catheter ablation of atrial fibrillation. MEASURES: The CCT protocol consisted of one angiographic phase and one delayed scan 30 s later. LAA thrombi were defined as solid masses on TEE or persistent defects on CCT. The thrombus dimension and location, the LAA filling and emptying flow velocity were assessed by TEE. RESULTS: Of the 57 (7.9%) patients with LAA thrombi identified by TEE, 29 (50.9%) were located at the LAA ostium, and 28 (49.1%) were in the LAA. The former showed higher motility following blood flow and heartbeats than the latter. The CCT detected 14 (48.3%) of the LAA-ostium thrombi but 25 (89.3%) of those in the LAA (p=0.001). The LAA-ostium thrombi with the LAA mean flow velocity >0.35 m/s and maximum diameters <10 mm were more prone to have CCT false-negative results. CONCLUSION: For patients undergoing catheter ablation for atrial fibrillation, CCT with a 30 s delay scan is less sensitive to LAA thrombi than TEE, especially for LAA-ostium thrombi with smaller sizes and higher LAA flow velocity.
Guo et al. (Mon,) conducted a case-control in atrial fibrillation (n=726). Cardiac CT (CCT) vs. Trans-oesophageal echocardiography (TEE) was evaluated on Detection of LAA-ostium thrombi versus LAA thrombi by CCT (p=0.001). Cardiac CT detected significantly fewer LAA-ostium thrombi compared to thrombi located within the LAA (48.3% vs 89.3%; p=0.001), with false negatives more common in smaller, high-flow ostium thrombi.
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