What question did this study set out to answer?

This study aims to describe characteristics of patients with Peyronie’s disease and compare those treated with penile prosthesis and grafting.

June 6, 2026

(565) Single-Center Experience in Surgical Management of Peyronie’s Disease: Comparative Analysis of Penile Prosthesis, Corporoplasty with Grafting, and Corporoplasty with Plication

Puntos clave

This study aims to describe characteristics of patients with Peyronie’s disease and compare those treated with penile prosthesis and grafting.
Retrospective review of 106 patients who underwent surgery for Peyronie’s disease from January 2022 to September 2025.
Demographic, cardiovascular comorbidities, lifestyle factors, and penile Doppler findings were analyzed.
Subgroup analysis compared penile prosthesis, corporoplasty with grafting, and corporoplasty with plication.
38% received penile prosthesis, 32% corporoplasty with plication, and 27% with grafting.
Patients with prosthesis were older (median 61.5 years) with higher rates of hypertension (50% vs 20.7%), type 2 diabetes (40% vs 6.9%), and dyslipidemia (50% vs 10.3%), all statistically significant (p<0.01).
Pathological findings in Doppler ultrasonography were significantly more prevalent in prosthesis patients (74% vs 3% in grafting; p<0.001).

Resumen

Abstract Introduction Peyronie’s disease (PD) is a fibrotic disorder of the tunica albuginea causing penile curvature and sexual dysfunction. Surgery is indicated in stable disease with functional impairment. We describe our single-center experience and compare the characteristics of patients treated with penile prosthesis and corporoplasty with plication or grafting. Objective The objective was to describe the characteristics of operated patients and to perform a subanalysis comparing those treated with penile prosthesis and with grafting. Methods We retrospectively reviewed all patients who underwent surgery for PD between January 2022 and September 2025. Demographic variables, cardiovascular comorbidities (hypertension HTN, type 2 diabetes mellitus T2D, dyslipidemia DLD), lifestyle factors (smoking, obesity), and penile Doppler findings were analyzed. Results A total of 106 patients underwent surgery for PD: 42 (38%) received a penile prosthesis, 35 (32%) underwent corporoplasty with plication, and 29 (27%) corporoplasty with grafting. Patients treated with penile prosthesis had a median age of 61.5 years (range 38–74), significantly higher than that of the grafting group, with a median age of 55 years (range 44–65; p0.001); plication patients had a median age of 62.5 years (range 30–76). Cardiovascular comorbidities were more frequent among prosthesis patients, with HTN present in 50% versus 20.7% in the grafting group (p=0.01), T2D in 40% versus 6.9% (p=0.003), and DLD in 50% versus 10.3% (p=0.002). In the plication cohort the prevalence of HTN, T2D and DLD was 29%, 11% and 20%, respectively. Smoking was common in all groups (69% prosthesis, 57% plication, 59% grafting; p=0.38 between prosthesis and grafting) and obesity rates were similar (17% prosthesis vs 17.2% grafting; p=1.0; 9% in plication). Penile Doppler ultrasonography was performed in 90% of prosthesis, 94% of plication, and 97% of grafting patients, showing pathological findings in 74%, 31%, and 3%, respectively (p0.001). Conclusions In our single-center cohort, patients treated with penile prosthesis were older and had a higher prevalence of cardiovascular comorbidities and pathological Doppler findings, consistent with more advanced disease and erectile dysfunction. Patients undergoing grafting were younger, with fewer comorbidities and mostly normal vascular studies. Patients in the plication group showed intermediate comorbidity rates. These findings highlight the need to tailor surgical strategies according to patient age, comorbidity profile, and vascular status. Disclosure No

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