What does this research mean for the field?

Porcine dermal, bovine pericardium, and collagen fleece xenografts yield similar long-term outcomes for penile straightening and overall patient satisfaction when used in corporoplasty for Peyronie's disease. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This study aims to compare the effectiveness of three different xenografts in treating Peyronie’s disease using grafting techniques.

June 6, 2026

(308) Comparative Study Between Three Different Xenografts in Corporoplasty for Surgical Treatment of Peyronie’s Disease

Key Points

This study aims to compare the effectiveness of three different xenografts in treating Peyronie’s disease using grafting techniques.
54 patients with Peyronie’s disease underwent grafting surgery using porcine dermal, bovine pericardium, or collagen fleece grafts.
Primary outcomes measured included the degree of curvature correction, while secondary outcomes involved penile rigidity and patient satisfaction.
Follow-up data was collected through questionnaires and self-photography to assess surgical outcomes.
Complete penile straightening was achieved in 75.5% of patients with no significant differences among the three graft groups (p = 0.18).
Patients using collagen fleece reported greater improvements in penile rigidity (50.0%) compared to the porcine (18.2%) and bovine (15.0%) groups (p < 0.05).
79.6% of patients indicated they would choose to undergo surgery again, with no statistical differences between graft groups (P = 0.69).

Abstract

Abstract Introduction Plaque incision/excision and grafting (PEG) is one of the mainstays in surgical therapy for severe penile curvature in Peyronie’s disease (PD). Different kinds of grafts are available for covering albugineal defects during PEG, both allografts and xenografts. However, to date, none of these proved superior to others. Objective The aim of this study was to compare three different types of xenograft, porcine dermal matrix, bovine pericardium matrix and collagen fleece matrix in PEG for PD. Methods From 2011 to 2023, 54 patients with PD underwent PEG, using porcine dermal (n = 15; Group 1), bovine pericardium (n = 20; Group 2) and collagen fleece-Tachosil (n=19; Group 3) grafts. Primary endpoint to evaluate the correction of the curvature in terms of residual curvature was evaluated through self-photography while secondary endpoints in terms of correction of penile bending, quality of erection, intercourse ability, penile shortening, and sensitiveness were evaluated through multi-disciplinary questionnaires administrated by phone interview Overall satisfaction and impact of surgery on sexual activity and quality of life were also investigated. The study obtained the approval of the local Ethical Committee. Results Plaque median (IQR) size was 28 (20-32.7) mm, without any statistically significant difference between patients of the three groups concerning plaque dimension, while 59% of overall patients had a penile curvature with an angle above 80°. Complete follow-up data were available for 54 patients. Considering post-operative outcomes, Complete penile straightening was obtained in 75.5% of patients, with no statistically significant differences between Group 1, 2 and 3 (63.6% vs. 75.0% vs. 83.3; p 0.18), no differences were found when considering penile shortening, sensitiveness, and complications (all P 0.05). Patients in Group 3 reported a greater improvement of penile rigidity compared to Group 1 and Group 2 (50.0% vs 18.2% vs 15.0% respectively P .05). However, patients’ post-operative sexual life was reported as improved in 54.5% of cases in Group 1, in 60.0% of cases in Group 2 and 61.1% in Group 3, while only 6 patients reported a worsened sexual life (p0.05). At follow-up, 79.6% of patients answered that would still undergo surgery for PD, with no statistical difference between the three groups (P = 0.69). Conclusions Corporoplasty with PEG is a safe and effective treatment for men with PD. Porcine dermal, bovine pericardium and Tachosil xenografts seem to have similar long-term outcomes. Disclosure No

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