What question did this study set out to answer?

To compare the surgical outcomes of polyglycolic acid polymer grafts and porcine small intestinal submucosa grafts in Peyronie’s disease treatment.

February 5, 2026

(O-06) Polyglycolic acid polymer versus porcine small intestine submucosa graft after plaque incision in Peyronie’s disease: a comparative study

Key Points

To compare the surgical outcomes of polyglycolic acid polymer grafts and porcine small intestinal submucosa grafts in Peyronie’s disease treatment.
Conducted a retrospective cohort study with two graft groups: polyglycolic acid (BioA group) and porcine graft (SIS group)
Included patients with Peyronie’s disease undergoing plaque incision and grafting
Measured outcomes included incidence of postoperative erectile dysfunction, penile curvature correction, and patient satisfaction using Likert scale.
The BioA group had a significantly higher rate of refractory erectile dysfunction compared to the SIS group (p = 0.006)
No significant differences in penile straightening, sensory alterations, or postoperative complications between the groups
Patient satisfaction was significantly higher in the SIS group (p = 0.015).

Abstract

Abstract Introduction Peyronie’s disease (PD) with severe penile curvature often requires surgical correction through plaque incision and grafting (PIG). Although various graft materials have been proposed for this procedure, no definitive evidence supports the superiority of one specific graft over others. Objective To compare surgical outcomes between polyglycolic acid polymer grafts (Gore® Bio-A®) and porcine small intestinal submucosa (SIS) grafts in patients undergoing PIG for PD. Methods Retrospective cohort study included patients with PD who underwent PIG using either Gore® Bio-A® (BioA group, n = 20) or SIS grafts (Cook Biotech; SIS group, n = 21). Subcoronal circumferential incision was made and in cases of dorsal curvature, the neurovascular bundle was meticulously dissected from the corpora cavernosa and for ventral curvatures, the urethra was mobilized. A double-Y relaxing incision was made in the tunica albuginea and the graft was placed. The primary outcome was the incidence of postoperative erectile dysfunction (ED) using Erection Hardness Score. Secondary outcomes included degree of penile curvature correction, sensory disturbances, patient satisfaction (Likert-scale), and surgical complications. Results Median age was 61 years in the BioA group and 57 years in the SIS group. In BioA group, dorsal curvature represented 50% and in SIS group dorsal curvature represented 47,6%. The BioA group exhibited a significantly higher rate of refractory ED compared to the SIS group (p = 0.006). No significant differences were observed between groups in terms of penile straightening, sensory alterations, postoperative complications, or the need for penile prosthesis implantation. Patient satisfaction was significantly higher in the SIS group (p = 0.015). Conclusion In this cohort, the SIS graft was associated with better postoperative outcomes than the BioA graft, with lower rates of refractory ED and higher patient satisfaction following PIG for PD. Financing No conflict.

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