Poor adherence to antihypertensive medications was associated with a significantly higher rate of left ventricular hypertrophy compared to good adherence (47.0% vs 4.5%, OR 0.02, p<0.001).
Cross-Sectional (n=150)
No
Does good adherence to antihypertensive medications reduce the prevalence of left ventricular hypertrophy in hypertensive patients?
Poor adherence to antihypertensive medications is highly prevalent and strongly associated with left ventricular hypertrophy in Nigerian outpatients.
Odds Ratio: 0.02 (95% CI 0.006–0.08)
Tasa de eventos absoluta: 47% vs 4.5%
valor p: p=<0.001
Background: Adherence to antihypertensive is crucial to treatment success in subjects with hypertension. This study is aimed at assessing antihypertensive drug adherence using validated tool and its relationship with some demographic and clinical parameters in outpatient hypertensive subjects. Methods:The Morisky Medication Adherence Scale (MMAS-4) was used to assess drug adherence status in 150 hypertensive patients who were consecutively recruited in a Medical Outpatient Department of a Tertiary Health Centre. All the patients had resting 12-lead electrocardiogram (ECG) done to determine left ventricular hypertrophy (LVH). Data were analyzed with SPSS 13 and statistical significance of p< 0.05 was used. Results: One hundred and fifty hypertensive patients with a mean age of 61.53 9.72years were recruited over a period of 6 months. Sixty seven (44.7%) were good drug adherers while 55.3% were not. Patients with poor antihypertensive adherence had higher p= 0.07) as well as longer P wave duration on ECG (0.15 0.03 vs. 0.12 0.04; p= 0.03). There was higher rate of ECG LVH among patients with poor drug adherence (47.0%) compared to patients with good drug adherence (4.5%). Significant correlates of poor drug adherence were age p=0.022) and BMI (r= 0.431; P<0.001).
Ebenezer Adekunle Ajayi (Tue,) conducted a cross-sectional in Hypertension (n=150). Poor adherence to antihypertensive medications vs. Good adherence was evaluated on Left ventricular hypertrophy (LVH) on ECG (OR 0.02, 95% CI 0.006 to 0.080, p=<0.001). Poor adherence to antihypertensive medications was associated with a significantly higher rate of left ventricular hypertrophy compared to good adherence (47.0% vs 4.5%, OR 0.02, p<0.001).