Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
January 1, 2013IOSR Journal of Dental and Medical SciencesOpen Access

Adherence to Antihypertensive Medications and Some of Its Clinical Implications in Patients Seen At a Tertiary Hospital in Nigeria

View Full Paper
Ask AI
Bookmark
Share

Key result

Poor adherence to antihypertensive medications was associated with a significantly higher rate of left ventricular hypertrophy compared to good adherence (47.0% vs 4.5%, OR 0.02, p<0.001).

Why the study?

Does good adherence to antihypertensive medications reduce the prevalence of left ventricular hypertrophy in hypertensive patients?

Population

150 hypertensive outpatients at a tertiary hospital in Nigeria, mean age 61.53 ± 9.72 years, 63 male and 87…

Comparison

Good adherence to antihypertensive medications vs Poor adherence to antihypertensive medications

Design

Cross-sectional

Authors

EAEbenezer Adekunle AjayiEkiti State University

Discussion

Loading...

Member takes

Implication

Should not yet change practice; cross-sectional data leaves open whether adherence interventions reduce LVH.

Study Design

Type

Cross-Sectional (n=150)

Multicenter

No

Structured PICO

Does good adherence to antihypertensive medications reduce the prevalence of left ventricular hypertrophy in hypertensive patients?

P
Population
150 hypertensive outpatients (mean age 61.5 years, 58% female) on antihypertensive medications were assessed for drug adherence and its clinical implications.
E
Exposure
Good adherence to antihypertensive medications (Morisky Medication Adherence Scale [MMAS-4] score ≥2)
C
Comparator
Poor adherence to antihypertensive medications (MMAS-4 score <2)
O
Outcome
Left ventricular hypertrophy (LVH) determined by resting 12-lead electrocardiogram (Sokolow-Lyon criteria)surrogate

Main Result

Odds Ratio: 0.02 (95% CI 0.006–0.08)

Absolute Event Rate: 47% vs 4.5%

p-value: p=<0.001

Poor adherence to antihypertensive medications is highly prevalent and strongly associated with left ventricular hypertrophy in Nigerian outpatients.

Limitations

  • MMAS-4 has the disadvantage of recall bias and eliciting socially acceptable responses, tending to overestimate adherence
  • Carried out in a tertiary health care setting, findings may not be applicable to the general population
  • Carried out in a single tertiary health care setting, limiting generalizability to the general population

Cite This Study

Ebenezer Adekunle Ajayi (2013) conducted a cross-sectional in Hypertension (n=150). Poor adherence to antihypertensive medications vs. Good adherence was evaluated on Left ventricular hypertrophy (LVH) on ECG (OR 0.02, 95% CI 0.006 to 0.080, p=<0.001). Poor adherence to antihypertensive medications was associated with a significantly higher rate of left ventricular hypertrophy compared to good adherence (47.0% vs 4.5%, OR 0.02, p<0.001).

synapsesocial.com/papers/6a2419f7637bef72baab37dahttps://doi.org/10.9790/0853-0843640
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Concurrent and Predictive Validity of a Self-reported Measure of Medication Adherence1986 · 5,387 citations
  2. 2Left ventricular hypertrophy increases cardiovascular risk independently of in-office and out-of-office blood pressure values2009 · 166 citations
  3. 32007 ESH-ESC Practice Guidelines for the Management of Arterial Hypertension2007 · 1,845 citations
  4. 4Factors Associated with Adherence to Anti-Hypertensive Treatment in Pakistan2007 · 249 citations
  5. 5Adherence to antihypertensive treatment and associated factors among patients on follow up at University of Gondar Hospital, Northwest Ethiopia2012 · 194 citations