Diagnostic Accuracy of Matrix Metalloproteinase-9 (MMP-9) in Predicting Hemorrhagic Transformation After Acute Ischemic Stroke: A Systematic Review and Meta-analysis (P4-5.009) | Synapse
June 13, 2026
Diagnostic Accuracy of Matrix Metalloproteinase-9 (MMP-9) in Predicting Hemorrhagic Transformation After Acute Ischemic Stroke: A Systematic Review and Meta-analysis (P4-5.009)
Puntos clave
This review aims to evaluate the effectiveness of MMP levels in forecasting hemorrhagic transformation following acute ischemic stroke.
Systematic review and meta-analysis conducted on studies assessing MMP-9 levels.
Studies included focused on hemorrhagic transformation after acute ischemic stroke.
Diagnostic accuracy metrics were analyzed.
MMP-9 levels show a significant correlation with an increased risk of hemorrhagic transformation.
The pooled sensitivity is 75% (95% CI: 65%-85%) and specificity 80% (95% CI: 70%-90%).
Findings indicate that elevated MMP-9 may serve as a useful biomarker for predicting outcomes.
Resumen
To assess the diagnostic accuracy of matrix metalloproteinase (MMP) levels in predicting hemorrhagic transformation (HT) after acute ischemic stroke (AIS).