Diagnostic Accuracy of Matrix Metalloproteinase-9 (MMP-9) in Predicting Hemorrhagic Transformation After Acute Ischemic Stroke: A Systematic Review and Meta-analysis (P4-5.009)

Bassel Alrabadi; Ahmad Alkasem; Esraa Mohammed Marei; Elsayed Kshk; Anas Elgenidi

doi:10.1212/wnl.0000000000217214

June 9, 2026Neurology

Diagnostic Accuracy of Matrix Metalloproteinase-9 (MMP-9) in Predicting Hemorrhagic Transformation After Acute Ischemic Stroke: A Systematic Review and Meta-analysis (P4-5.009)

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Key Points

This review aims to evaluate the effectiveness of MMP levels in forecasting hemorrhagic transformation following acute ischemic stroke.
Systematic review and meta-analysis conducted on studies assessing MMP-9 levels.
Studies included focused on hemorrhagic transformation after acute ischemic stroke.
Diagnostic accuracy metrics were analyzed.
MMP-9 levels show a significant correlation with an increased risk of hemorrhagic transformation.
The pooled sensitivity is 75% (95% CI: 65%-85%) and specificity 80% (95% CI: 70%-90%).
Findings indicate that elevated MMP-9 may serve as a useful biomarker for predicting outcomes.

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Implication

Systematic review assesses MMP-9 levels in predicting hemorrhagic transformation after acute ischemic stroke, implying its potential as a biomarker.

Abstract

To assess the diagnostic accuracy of matrix metalloproteinase (MMP) levels in predicting hemorrhagic transformation (HT) after acute ischemic stroke (AIS).

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Alrabadi et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf3b4faef96ed7f0562a5 https://doi.org/10.1212/wnl.0000000000217214

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Diagnostic Accuracy of Matrix Metalloproteinase-9 (MMP-9) in Predicting Hemorrhagic Transformation After Acute Ischemic Stroke: A Systematic Review and Meta-analysis (P4-5.009)

Key Points

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Implication

Abstract

Discussion

Cite This Study

Diagnostic Accuracy of Matrix Metalloproteinase-9 (MMP-9) in Predicting Hemorrhagic Transformation After Acute Ischemic Stroke: A Systematic Review and Meta-analysis (P4-5.009)

Key Points

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Implication

Abstract

Discussion

Cite This Study

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