A 1 kg/m² higher BMI in middle age was associated with a 21% higher risk of type 2 diabetes (HR 1.21; 95% CI 1.18-1.24), 6% higher risk of MI, and 4% higher risk of stroke over 30 years.
Cohort (n=7,735)
Does higher BMI in early and middle adulthood increase the risk of myocardial infarction, stroke, and type 2 diabetes in men?
Higher BMI in middle age is strongly associated with incident MI, stroke, and diabetes, whereas higher BMI in early adulthood is associated with later diabetes risk but not cardiovascular events.
Hazard Ratio: 1.21 (95% CI 1.18–1.24)
OBJECTIVES: Adiposity in middle age is an established risk factor for cardiovascular disease and type 2 diabetes; less is known about the impact of adiposity from early adult life. We examined the effects of high body mass index (BMI) in early and middle adulthood on myocardial infarction (MI), stroke and diabetes risks. DESIGN: A prospective cohort study. PARTICIPANTS: 7735 men with BMI measured in middle age (40-59 years) and BMI ascertained at 21 years from military records or participant recall. PRIMARY AND SECONDARY OUTCOME MEASURES: 30-year follow-up data for type 2 diabetes, MI and stroke incidence; Cox proportional hazards models were used to examine the effect of BMI at both ages on these outcomes, adjusted for age and smoking status. RESULTS: Among 4846 (63%) men (with complete data), a 1 kg/m(2) higher BMI at 21 years was associated with a 6% (95% CI 4% to 9%) higher type 2 diabetes risk, compared with a 21% (95% CI 18% to 24%) higher diabetes risk for a 1 kg/m(2) higher BMI in middle age (hazard ratio (HR) 1.21, 95% CI 1.18 to 1.24). Higher BMI in middle age was associated with a 6% (95% CI 4% to 8%) increase in MI and a 4% (95% CI 1% to 7%) increase in stroke; BMI at 21 years showed no associations with MI or stroke risk. CONCLUSIONS: Higher BMI at 21 years of age is associated with later diabetes incidence but not MI or stroke, while higher BMI in middle age is strongly associated with all outcomes. Early obesity prevention may reduce later type 2 diabetes risk, more than MI and stroke.
Owen et al. (Tue,) conducted a cohort in Myocardial infarction, stroke and type 2 diabetes (n=7,735). Higher body mass index (BMI) in early and middle adulthood vs. Lower BMI (per 1 kg/m2 increase) was evaluated on Type 2 diabetes incidence (HR 1.21, 95% CI 1.18 to 1.24). A 1 kg/m² higher BMI in middle age was associated with a 21% higher risk of type 2 diabetes (HR 1.21; 95% CI 1.18-1.24), 6% higher risk of MI, and 4% higher risk of stroke over 30 years.