Key result
A 1 kg/m² higher BMI in middle age was associated with a 21% higher risk of type 2 diabetes (HR 1.21; 95% CI 1.18-1.24), 6% higher risk of MI, and 4% higher risk of stroke over 30 years.
Why the study?
Does higher BMI in early and middle adulthood increase the risk of myocardial infarction, stroke, and type 2 diabetes in men?
Population
7735 men with BMI measured in middle age and BMI ascertained at 21 years from military records or…
Design
Cohort
Follow-up
30 years
Authors
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Early high BMI associated with diabetes but not MI/stroke; leaves open optimal prevention timing and causal effects.
Cohort (n=7,735)
Does higher BMI in early and middle adulthood increase the risk of myocardial infarction, stroke, and type 2 diabetes in men?
Hazard Ratio: 1.21 (95% CI 1.18–1.24)
Higher BMI in middle age is strongly associated with incident MI, stroke, and diabetes, whereas higher BMI in early adulthood is associated with later diabetes risk but not cardiovascular events.
Owen et al. (2015) conducted a cohort in Myocardial infarction, stroke and type 2 diabetes (n=7,735). Higher body mass index (BMI) in early and middle adulthood vs. Lower BMI (per 1 kg/m2 increase) was evaluated on Type 2 diabetes incidence (HR 1.21, 95% CI 1.18 to 1.24). A 1 kg/m² higher BMI in middle age was associated with a 21% higher risk of type 2 diabetes (HR 1.21; 95% CI 1.18-1.24), 6% higher risk of MI, and 4% higher risk of stroke over 30 years.
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