At a steady state far from equilibrium, the force exerted by individual myosin cross-bridges can generate a nonzero average isometric force that far exceeds the macroscopic phase-transition force.
Theoretical analysis suggests that an equilibrium phase transition cannot be the basic feature in muscular contraction because isometric force decreases linearly with increasing length.
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans the biological, physical, and social sciences.
Terrell L. Hill (Sun,) conducted a other in Muscular contraction (theoretical model). Theoretical thermodynamic and kinetic modeling was evaluated. At a steady state far from equilibrium, the force exerted by individual myosin cross-bridges can generate a nonzero average isometric force that far exceeds the macroscopic phase-transition force.
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