Key result
At a steady state far from equilibrium, the force exerted by individual myosin cross-bridges can generate a nonzero average isometric force that far exceeds the macroscopic phase-transition force.
Population
Theoretical model of muscular contraction (actin-myosin filament system)
Design
Other
Authors
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Level 5 evidence remains hypothesis-generating; leaves open need for confirmatory trials before clinical consideration.
Theoretical analysis suggests that an equilibrium phase transition cannot be the basic feature in muscular contraction because isometric force decreases linearly with increasing length.
Terrell L. Hill (1968) studied Muscular contraction (theoretical model). Theoretical thermodynamic and kinetic modeling was evaluated. At a steady state far from equilibrium, the force exerted by individual myosin cross-bridges can generate a nonzero average isometric force that far exceeds the macroscopic phase-transition force.
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