ABSTRACT Background Controversy persists over whether preimplantation genetic testing (PGT) increases adverse maternal and neonatal outcomes. Objectives To quantify the risk of maternal and neonatal outcomes for singleton and multiple pregnancies conceived after PGT versus those conceived after IVF/ICSI. Search Strategy PubMed, Embase, Web of Science, and Cochrane Central Register of Controlled Trials were searched from January 1990 to May 2025. Selection Criteria Randomised controlled trials (RCTs) and observational studies separately reporting outcomes in singleton and multiple pregnancies. Data Collection and Analysis Random‐effects models were used for calculating relative risks (RRs) or standardised mean differences (SMDs) with 95% confidence intervals (CIs). Main Results Forty‐two studies (43 663 PGT cases and 217 002 IVF/ICSI cases) were included for further analysis. The risks of very low birth weight (VLBW) (RR 0.66; 95% CI 0.58, 0.76), preterm birth (PTB) < 34 weeks (RR 0.79; 95% CI 0.73, 0.86), PTB < 32 weeks (RR 0.68; 95% CI 0.52, 0.89), and PTB < 28 weeks (RR 0.59; 95% CI 0.35, 0.99) in PGT singleton pregnancies were significantly lower than those in IVF/ICSI singleton pregnancies, and the risk of PTB < 32 weeks (RR 0.62; 95% CI 0.45, 0.86) in PGT multiple pregnancies was notably reduced compared to that in IVF/ICSI multiple pregnancies. The two groups showed comparable maternal outcome risks in singleton and multiple pregnancies. Conclusions Nonetheless, no decisive conclusions can be drawn due to the low quality of evidence and challenges of statistical hypothesis testing. Additional high‐quality RCTs with larger sample sizes and stringent methodologies are warranted to validate these findings.
Luo et al. (Mon,) studied this question.
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