July 31, 2025

Enhanced SAR understanding of jasplakinolide-like natural products and analogs

VNVeselin NasufovićSchiller International University MBMerle BlümkeSchiller International University FKFlorian KüllmerSchiller International University

Key Points

MAIN FINDING: The study enhances understanding of jasplakinolide-like compounds and their effects on F-actin.
KEY EVIDENCE: Different synthetic compounds were assessed in vitro and in cellulo, revealing insights into their biological activity.
APPROACH: A focused library of cyclic peptides was synthesized using an optimized strategy for structure-activity analysis.
SIGNIFICANCE: Improved understanding of these natural products may advance tools for cell biology and influence future research.

Abstract

Jasplakinolide-like natural products and their analogs are F-actin-stabilizing cyclic pep-tides which are widely used in cell biology as tools for visualization and modulation of actin-dependent processes. In this study, we report the synthesis of a focused library of different compounds using an optimized synthetic strategy. Comprehensive in vitro and in cellulo evaluation facilitated a deeper understanding of structure-activity relationships (SAR) and resolved conflicting data concerning jasplakinolide H.

Demander à l'IA

Bookmark

View Full Paper