ABSTRACT Acinic cell carcinoma (ACC) is a rare malignant tumor of the head and neck region. It accounts for 12.4%–17.4% of parotid gland malignancies and approximately 3.4% of all salivary gland tumors. ACC is a low‐grade salivary gland malignancy that predominantly affects females. In some cases, ACC can undergo high‐grade transformation (HGT), resulting in more aggressive behavior. Here, we present a rare case of recurrent Acinic cell carcinoma with aggressive features and high‐grade cytomorphology—including increased cellularity, papillary and singly scattered cells, high nuclear‐to‐cytoplasmic (N:C) ratio, coarse chromatin, and single‐cell necrosis in the background—diagnosed via fine‐needle aspiration cytology (FNAC) and further confirmed by histopathology and immunohistochemistry. This case can be categorized as ACC recurrence associated with high‐grade transformation (HGT).
Khairwa et al. (Wed,) studied this question.
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