August 15, 2025Frontiers in Medicine0 citationsOpen Access

Case Report: Membranous nephropathy associated with mantle cell lymphoma: a rare case

MRMian RenZhejiang Provincial People's Hospital LCLuxi CaoZhejiang Provincial People's Hospital QSQuanquan ShenLanzhou University Second Hospital

Key Points

Complete remission of nephrotic syndrome was achieved after modified R-CHOP therapy, leading to better kidney health.
A 67-year-old man presented nephrotic syndrome and impaired renal function, with a diagnosis confirmed through kidney biopsy.
This case utilized a specific chemotherapy protocol, highlighting the potential for effective treatment of malignancy-associated kidney conditions.
Successful treatment outcomes suggest further investigation into tailored therapies for secondary kidney diseases linked to cancers.

Abstract

Mantle cell lymphoma (MCL) is a rare, aggressive non-Hodgkin lymphoma (NHL) that can affect the kidneys. In this research, we described a very rare case of secondary membranous nephropathy (MN) associated with MCL. A 67-year-old man manifested with impaired renal function and nephrotic syndrome (NS). Kidney biopsy revealed atypical MN and MCL cell infiltration. After eight rounds of modified R-CHOP therapy, which includes rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone, the patient achieved complete remission, accompanied by improved renal function and a reduction in proteinuria. This case demonstrates the precise diagnosis and treatment of the primary disease, which can lead to favorable outcomes.

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