Background: Diabetes Mellitus (DM) is a global metabolic disorder, characterized by chronic hyperglycemia and associated symptoms such as polyuria, polydipsia, and polyphagia. Prameha, a disease condition described in Ayurvedic texts, shares strong pathophysiological and clinical similarities with diabetes mellitus. Ayurveda offers a range of herbo-mineral formulations for Prameha management, among which Vangeshwara Rasa is frequently cited in classical texts. Objective: This study aims to critically examine classical Ayurvedic references to Vangeshwara Rasa and analyze its potential role in the management of Prameha (diabetes mellitus), supported by contemporary clinical and pharmacological evidence. Materials and methods: A total of 21 classical Ayurvedic references for Vangeshwara Rasa were reviewed, of which 15 were indicated specifically for Prameha and included in the analysis. Key ingredients such as Rasasindura (Red Sulfide of Mercury) and Vanga Bhasma (Tin Ash) were examined for their therapeutic relevance based on Ayurvedic principles and modern studies. Results: Most formulations share common core ingredients but vary in complexity. Pharmacological properties of Rasasindura and Vanga Bhasma suggest actions like Agni Deepana, Kleda Shoshana, and Medohara, which directly address the pathogenesis of Prameha. Modern studies indicate improvements in glycemic parameters, subjective symptoms, and diabetic complications, with good safety profiles. Conclusion: Vangeshwara Rasa represents a promising Ayurvedic formulation for the integrative management of Prameha. Further standardization and clinical validation are essential to establish its evidence-based utility in diabetes care.
Khanal et al. (Wed,) studied this question.
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