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August 25, 2025Open Access

Gestational Trophoblastic Neoplasia: Evaluation of Prognostic Factors, Mode of Treatment and Responses

Key Points

Most patients presented with amenorrhea and per vaginal bleeding, highlighting common symptoms of gestational trophoblastic disease.
Among the cases, 70% were diagnosed with hydatidiform mole, and 80% had normal serum bhCG levels within 6-8 weeks after treatment.
Patients were treated mainly via suction evacuation, while some required chemotherapy for persistent GTN or choriocarcinoma.
Identification of risk factors remains challenging, implying a need for further research to clarify trends in gestational trophoblastic disease.

Abstract

Background: Gestational Trophoblastic Disease (GTD) represents a spectrum of neoplastic disorders that arise from placental trophoblastic tissue after abnormal fertilization. The exact etiology of gestational trophoblastic disease is yet unknown. It arises from placental villous and extra villous trophoblast. Proper evaluation and appropriate treatment canreduce the complication of GTD. To evaluate the risk factorsfor optimum treatment according to risk group and response to treatment. Materials and methods: This observational cross-sectional study was conducted in Dhaka Medical College Hospital between 27 th April 2019 and 26 th October 2019.A total of fifty patients having Gestational Trophoblastic Disease (GTD) admitted in Department of Obstetrics 34 (2) : 8-13

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