Modern approaches to the treatment of patients based on a high degree of individualization of therapy, attention to patient compliance and ease of use of drugs determine the vector for the development and further improvement of traditional dosage forms, such as tablets. Optimization of the composition and technological processes allows the creation of highly effective, stable and easy-to use tablets dispersed in the oral cavity (orodispersible tablets, ODT). To obtain them, both traditional tablet manufacturing technologies, such as direct compression, compression with preliminary wet or structural granulation, and some innovative technological processes are applicable. The composition of excipients in ODT is maximally unified with conventional tablets, differing mainly in the quantitative ratios of the components, in particular, a significant increase in the proportion of disintegrants and the use of superdisintegrants. A reasonable expansion of the range of tablet dosage forms due to ODT is a rather promising direction in the development of tablet technology.
Vasilievna et al. (Mon,) studied this question.