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September 5, 2025Open Access

Thrombosis in Brothers With Protein S Deficiency: Case Series

Key Points

Thrombosis risk is significantly elevated in individuals with protein S deficiency, particularly affecting unusual sites.
Key evidence suggests early diagnosis and long-term anticoagulation can significantly improve outcomes in affected families.
Observational analysis of brothers with hereditary protein S deficiency reveals patterns of VTE and associated complications.
Early familial screening for protein S deficiency may allow for preventative measures and reduced complications in relatives.

Abstract

ABSTRACT Hereditary protein S deficiency is a rare thrombophilia that increases the risk of venous thromboembolism (VTE), including thrombosis in unusual sites. Early diagnosis, familial screening, and long‐term anticoagulation are essential for preventing complications and improving outcomes.

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