What type of study is this?

This is a Mathematical Model study (also classified as: Stochastic Queuing Model).

September 5, 2025Open Access

Does GLUT4 Queue? A Mechanistic Mathematical Model for Insulin Response in Adipocytes

BSBrock D. SherlockEindhoven University of Technology MBMarko BoonEindhoven University of Technology MVMaria VlasiouEindhoven University of Technology

Key Points

Changing fusion sites alone can explain how insulin affects GLUT4 dynamics in adipocytes.
The model reveals GLUT4 translocation relies on insulin regulation and the availability of fusion sites.
A stochastic queuing model illustrates the interaction between insulin signaling and GLUT4 distribution.
Understanding GLUT4 dynamics is essential for insights into glucose regulation and insulin response.

Abstract

Abstract Mammalian cells regulate their glucose levels by redistributing glucose transporter proteins within the cell. Glucose Transporter 4 (GLUT4) is the main insulin-regulated glucose transporter in mammalian cells. Insulin signals the redistribution of GLUT4 from intracellular compartments to the cell surface. The mechanisms of the release of GLUT4 and subsequent transport to the plasma membrane remain an open question. Here, a biologically plausible model of GLUT4 translocation is presented. Using a stochastic queuing model, we find that changing only the number of fusion sites available for GLUT4-containing vesicles as a function of insulin is sufficient to explain experimental observations. Thus, the activity of the fusion sites could be the primary determinant of the dynamics of GLUT4.

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Cite This Study

Sherlock et al. (Tue,) studied this question.

synapsesocial.com/papers/68bb5f266d6d5674bcd03260 https://doi.org/https://doi.org/10.1007/s11538-025-01490-6

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