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September 5, 2025

High-density lipoprotein cholesterol at admission reflects disease course, severity, and influences management decisions in patients with amoebic liver abscess

Key Points

Lower levels of high-density lipoprotein cholesterol indicate more severe amoebic liver abscess cases, influencing treatment decisions.
HDL-C acts as a better predictor of disease severity than traditional inflammatory markers like C-reactive protein.
Assessment of serum lipid profiles provides insights into complications of amoebic liver abscess in patients during hospital stays.
Improvement in HDL-C levels post-treatment highlights its potential as a low-cost biomarker for clinical assessment.

Abstract

Amoebic liver abscess (ALA) remains a major health burden in tropical regions. Our observational study evaluated the association between serum lipid profiles and disease severity in 118 patients with ALA. Patients were classified into uncomplicated and complicated ALA groups. Serum high-density lipoprotein cholesterol (HDL-C) levels were significantly lower in ALA patients compared to controls and further reduced in complicated cases. HDL-C emerged as an independent predictor of complicated ALA and demonstrated better predictive value than conventional inflammatory markers such as total leucocyte count and C-reactive protein. Lower HDL-C levels were also linked to an increased need for percutaneous catheter drainage and longer hospital stay. Post-treatment assessments showed significant improvement in HDL-C levels. These findings suggest that HDL-C is a valuable, low-cost biomarker for assessing ALA severity and guiding clinical decisions, especially in resource-limited settings.

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