A novel system based on a task-specific pyrrolinium-based ionic liquid and homogeneous in situ solvent formation microextraction for the determination of sertraline in real water and urine samples

Key Points

• The HISFME method achieved efficient extraction of sertraline from urine and water samples without harmful solvents.
• Phase separation triggered by NaBF4 resulted in a selective extraction process that enhances extraction efficiency.
• Unlike traditional methods, this novel technique utilizes task-specific ionic liquids, showing improved environmental sustainability.
• The system facilitates trace pharmaceutical analysis, highlighting its potential in environmental monitoring and public health.