ABSTRACT Background Parkinson's disease (PD) manifestations involve respiratory dysfunction and motor disability. Previous research on PD has mainly focused on central dopamine (DA) deficits and their effect on ventilation. Objectives The purpose of the study was to analyze the function of carotid bodies (CB), sensors of blood O 2 , by studying the hypoxic ventilatory response (HVR) and measuring biogenic amine content in the CB of a 6‐hydroxydopamine (6‐OHDA) induced PD model. We also investigated the effects of supplementation with the DA biosynthesis precursor L‐DOPA on HVR and central DA depletion on hypoxic phrenic (PHR) and hypoglossal (HG) nerve activity. Methods After 6‐OHDA intrastriatal injection, awake Wistar rats were tested in a plethysmographic chamber to study the HVR (8% O 2 ) before and after L‐DOPA treatment. Registration of PHR and HG under acute hypoxia (8% O 2 ) was performed in anesthetized rats. Results The 6‐OHDA rats showed reduced normoxic ventilation and HVR, eliminated by L‐DOPA treatment. Increased HG activity during hypoxia in the form of increased amplitude and pre‐inspiratory amplitude was observed. In addition to decreased striatal levels of DA, serotonin (5‐HT) and noradrenaline (NA), reduced NA (42%) and 5‐HT (52%) were found in CB of 6‐OHDA rats. The open‐field test showed a decrease in motor activity 2 weeks after the lesion. Conclusions Our results showed NA and 5‐HT deficits in CB in the PD model, which may be responsible for impaired HVR. L‐DOPA treatment, replenishing DA deficiency in the striatum, stimulated HVR. Increased pre‐inspiratory HG activity indicates modifications to the central mechanisms controlling their activity.
Andrzejewski et al. (Fri,) studied this question.
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