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This is a Literature Review study.

September 10, 2025

A comprehensive review on analytical methods of Raltegravir

Key Points

Raltegravir, the first FDA-approved integrase strand transfer inhibitor, is crucial for HIV therapy.
Over 30 analytical techniques including UV spectrophotometry and LC-MS/MS are evaluated for their ability to quantify raltegravir.
Techniques are assessed based on sensitivity, specificity, and validation, guiding researchers in method selection.
The review emphasizes methods suitable for routine analysis, pharmacokinetics, and stability of raltegravir.

Abstract

Raltegravir, an integrase strand transfer inhibitor (INSTI), is the first FDA-approved drug in its class for HIV therapy.Due to its clinical significance, a variety of analytical methods have been developed for its quantification in pharmaceutical formulations and biological matrices. This review comprehensively compiles 30+ analytical techniques including UV spectrophotometry,RPHPLC, HPTLC, UPLC, LC-MS/MS, and electrochemical methods, evaluating their sensitivity, specificity, and validation status.The aim is to guide researchers in selecting suitable methods for routine, pharmacokinetic,and stability analysis of Raltegravir.

A comprehensive review on analytical methods of Raltegravir

Key Points

Abstract

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