What type of study is this?

This is a Experimental Study study.

September 17, 2025

Fat-corrected APTw/CEST-MRI with timed breathing for renal applications

Key Points

Good suppression of fat artifacts was achieved, allowing better evaluation of the renal substructure.
Initial results indicate that APTw/CEST-MRI using z-spectral fitting can effectively reduce motion artifacts.
The use of timed breathing during MRI acquisitions improved data quality in renal applications.
This approach opens new avenues for renal imaging, providing potential benefits for cancer diagnosis and transplant assessments.

Abstract

Motivation: APTw/CEST MRI in renal imaging would be useful for many ailments, such as characterization of small renal masses in cancer or kidney injury/transplants. However, fat and motion artifacts remain challenging. Goal(s): Assess feasibility of in vivo fat-correction in renal CEST-MRI using previously introduced Z-spectral fitting of SPIR fat-suppressed data. Approach: APTw/CEST data was acquired using single-shot fast-spin-echo MRI with compressed-sensing acceleration and timed-breathing in volunteers. Background model fitting (olefinic/aliphatic fat, water/MT, SPIR effect) is used for fat-correction in APTw imaging. Results: Initial renal CEST-MRI using Z-spectral background-fitting was demonstrated with good suppression of fat and detailed substructure of CEST effect in the organ. Impact: Enable CEST applications in the kidney with low artifact level from fat.

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