What type of study is this?

This is a Experimental Study study.

September 17, 2025

Concurrent SORDINO fMRI and Calcium Imaging at Cellular Resolution Reveal Prefrontal Cortex Integration with Brain Networks

Key Points

This approach reveals multiple network correlates with distinct cellular clusters in the medial prefrontal cortex, enhancing our understanding of neuron integration.
Cellular resolution measurements show significant brain network dynamics, indicating the complexity of neuronal interactions within the cortex.
Using MR-compatible calcium imaging alongside fMRI, researchers captured both cellular activity and large-scale network dynamics effectively.
This novel multimodal imaging method may enable further exploration of questions regarding brain networks unaddressed by previous techniques.

Abstract

Motivation: To investigate how regional neuronal activity from distinct cellular clusters are associated with fMRI-derived large-scale brain networks. Goal(s): To develop a multimodal imaging platform for awake mice, bridging knowledge across measurement scales and modalities. Approach: Using MR-compatible calcium imaging at cellular resolution to simultaneously measure fMRI network dynamics and cellular activity in awake mice. Results: This platform reveals multiple network correlates with distinct cellular clusters within the mouse medial prefrontal cortex, suggesting spatial integration of these functionally segregated neurons in an evolutionarily conserved species. Impact: We introduce a radically new approach combining brain-wide fMRI and cellular-level calcium imaging, enabling researchers to tackle brain network questions previously beyond reach.

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Cite This Study

Hsu et al. (Tue,) studied this question.

synapsesocial.com/papers/68d4597b31b076d99fa5c9ca https://doi.org/https://doi.org/10.58530/2025/1530

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