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September 17, 2025

Meal-induced changes of proton density fat fraction and T2* in supraclavicular adipose tissue

Key Points

Activation of brown adipose tissue by meals led to significant decreases in both proton density fat fraction and T2*.
PMRI measurements showed a notable drop in PDFF and T2* in activated brown adipose tissue compared to fasting control.
Twelve participants underwent MRI scans post-meal and post-fasting to measure changes in brown adipose tissue activation.
Findings may indicate new metabolic pathways initiated by dietary intake in human brown adipose tissue.

Abstract

Motivation: Investigating brown adipose tissue (BAT) non-invasively has attracted attention as BAT may serve as a target for treating metabolic diseases. Goal(s): To investigate meal-induced changes in activated human BAT. Approach: Ten volunteers received isocaloric meals after fasting (activation experiment). MRI was performed at baseline and one hour post-meal using 12-echo radial stack-of-stars Dixon scans to assess proton density fat fraction (PDFF) and T2*changes. MRI was also performed after fasting without meals (control experiment) at baseline and one hour post-fasting. Results: PDFF and T2* decreased significantly in the activation experiment compared to control. Both parameters showed a simultaneously decreasing trend in the same voxels. Impact: Human brown adipose tissue (BAT) is metabolically activated by meal consumption. Comparing proton density fat fraction (PDFF) and T2* changes between activation and control experiments, this study is the first to give insights into postprandial responses of BAT using MRI.

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Cite This Study

Raspe et al. (Tue,) studied this question.

synapsesocial.com/papers/68d4597b31b076d99fa5cd9f https://doi.org/https://doi.org/10.58530/2025/3526

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