Motivation: Intravoxel incoherent motion (IVIM) provides a non-invasive alternative for perfusion imaging, but clinical adoption needs to be facilitated by evaluating quantitative measures for assessing changes in perfusion. Goal(s): To evaluate different statistical ROI measures for the perfusion fraction (f) and relative cerebral blood volume (rCBV) and assess their impact on the perfusion estimation. Approach: MRI data of 31 primary tumor patients were analyzed. Four different statistical measures for f and rCBV were estimated in tumor and normal-appearing white matter. Results: The interpercentile range of perfusion estimates captured a homogeneous perfusion estimation in normal-appearing white matter and demonstrated heterogenously increased perfusion in tumor tissue. Impact: The interpercentile range of f and rCBV captured a homogeneous perfusion estimation in normal-appearing white matter and demonstrated heterogenously increased perfusion in tumor tissue. The choice of statistical ROI measure can impact the clinical interpretation of quantitative perfusion metrics.
Rosenqvist et al. (Tue,) studied this question.
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