Quinoline compounds and their derivatives have a vast distribution in nature coupled with their immense therapeutic potential. Due to the unfading therapeutic benefits of these compounds over the years, a lot of researchers are exploring the synthesis of various derivatives of quinoline which are screened for different therapeutic activities including, anti-malarial, anti-microbial, anti-inflammatory, anti-convulsant, anti-cancer anti-mycobacterial, cardio-protective, neuroprotective activity etc. This review highlights various advances in the synthetic routes and methodology for some quinoline derivatives including Friedlander modified metal-catalyzed reactions, Photo-induced oxidative annulation reaction, Microwave-assisted doebner reaction and their biological properties.
Nnadi et al. (Wed,) studied this question.
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