Supplementary Figure S7 from Alzheimer's Disease–Associated Amyloid-β Precursor Protein Prevents Aging Stress–Induced Mitophagy and Fumarate Depletion to Improve Antitumor Immunity

Key Points

• Increased APP levels in T-cells correlate with reduced mitophagy in Alzheimer's disease patients with cancer.
• Cytokine production is observed to rise alongside APP elevation, suggesting immune response changes in these patients.
• Loss of mitophagy could lead to unfavorable metabolic changes, potentially impacting antitumor immunity.
• The findings hint at APP's dual role in Alzheimer's pathology and immune modulation against tumors.