The single-phase CTA Clot Burden Score is independently associated with DSA ASITN collateral score

Abstract Objectives The variation in quality and quantity of collateral status (CS) is in part responsible for a wide variability in extent of neural damage following acute ischemic stroke from large vessel occlusion (AIS-LVO). Single-phase CTA based clot burden score (CBS) is a promising marker in estimating CS. The aim of this study is to assess the relationship of pretreatment CTA based CBS with the reference standard Digital subtraction angiography (DSA) based American Society of Interventional and Therapeutic Neuroradiology (ASITN) CS. Methods In this retrospective study, inclusion criteria were as follows: (1) Anterior circulation LVO confirmed on CTA from January 9, 2017 to January 10, 2023; (2) diagnostic CTA; and (3) underwent mechanical thrombectomy with documented DSA CS. Spearman’s rank correlation analysis, multivariate logistic regression and ROC analysis was performed to assess the correlation of CTA CBS with DSA CS. P ≤ .05 was considered significant. Results 292 consecutive patients (median age = 68 years; 56.2% female) met our inclusion criteria. CTA CBS and DSA CS showed significant positive correlation (ρ = 0.51, P .001). On multivariate logistic regression analysis CBS was found to be independently associated with DSA CS (adjusted OR = 1.83, P .001, 95% CI: 1.54-2.19), after adjusting for age, sex, race, hyperlipidemia, hypertension, diabetes, prior stroke or transient ischemic attack, atrial fibrillation, premorbid mRS, admission NIH stroke scale, and ASPECTS. ROC analysis of CBS in predicting good DSA CS showed AUC of 0.76 (P .001; 95% CI: 0.68-0.82). CBS threshold of 6 has 84.6% sensitivity and 42.3% specificity in predicting good DSA CS. Conclusion CTA CBS is independently associated with DSA CS and serves as a valuable supplementary tool for CS estimation. Further research is necessary to enhance our understanding of the role of CTA CBS in clinical decision-making for patients with AIS-LVO. Advances in knowledge CBS by indirectly estimating CS has shown to predict outcomes in AIS-LVO patients. No studies report association of CBS with reference standard DSA. In this study we further establish CBS as an independent marker of CS.