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This study aims to investigate the prevalence of these adhesion genes in P. mirabilis strains isolated from patients with UTIs. The research seeks to provide insights into the distribution and potential role of these virulence factors. Understanding the prevalence and molecular mechanisms of mrpA and ZapA could contribute significantly to the development of targeted therapies and preventive strategies against P. mirabilis infections. Proteus mirabilis is a significant opportunistic pathogen known for causing urinary tract infections (UTIs) and other infections, posing a considerable public health challenge. The pathogenicity of P. mirabilis is complex and multifactorial, attributed to a range of virulence factors that enable the bacterium to colonize, invade, and persist within host tissues. Among these, adhesion genes like mrpA and ZapA play a crucial role in facilitating attachment, biofilm formation, and immune evasion. The mrpA gene is integral to the pathogenesis of Proteus mirabilis. It encodes a major component of the MR/P fimbriae, which is essential for bacterial adhesion to host tissues, biofilm formation, immune evasion, and persistence in the urinary tract. By facilitating these processes, the mrpA gene contributes significantly to the virulence of P. mirabilis and its ability to cause complex urinary tract infections. Understanding the role of mrpA in the pathogenesis of P. mirabilis could aid in the development of targeted therapies to prevent and treat infections caused by this bacterium.
Yaseen et al. (Wed,) studied this question.