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Intravoxel Incoherent Motion (IVIM) is a non-contrast MR diffusion-based scan that uses a multitude of b-values to measure various speeds of molecular perfusion and diffusion, sidestepping problems of Gd-contrast or increased transit time in neurovascular disease. Quantification of IVIM CBF in ml/100g/min using pseudo-diffusion mean transit time led to strong Wilcoxon signed rank agreement, similar sensitivity, and a small offset compared to microsphere perfusion across three physiologic states. This suggests IVIM can be used to quantify CBF in ml/100g/min in a setting of cerebral steno-occlusive disease.
Liu et al. (Wed,) studied this question.
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