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Quantitative MRI allows the characterization and comparison of microstructural tissue properties and, by defining normative ranges for healthy tissue, detection of pathology. The simultaneous evaluation of multiple qMRI measures facilitates the understanding of what biological mechanisms underlie the observed deviations in relaxometry. Here, we introduce the ratio between quantitative T2 and T1 maps (T2/T1) as a microstructural property whose deviations from normative values could be predictive or characteristic of brain pathologies. A T2/T1 voxel-wise normative atlas was created and allowed characterization of tissue changes in two multiple sclerosis patients, providing complementary information to the existing T1 and T2 atlases.
Ravano et al. (Wed,) studied this question.