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Diagnosis of prostate cancer (PCa) remains a challenge since PCa often occurs simultaneously with benign prostatic hyperplasia and has similar nodule appearance on T2-weighted imaging and diffusion weighted imaging. Amide proton transfer weighted (APTw) imaging is an endogenous biomarker to detect proteins and peptides in tissues non-invasively. Results of this study indicate the APTw ratio (rAPTw) values of PCa were significantly higher than those of prostate benign nodules. Therefore, rAPTw value is potentially a promising and valuable non-invasive biomarker in differentiating PCa from benign nodules.
He et al. (Wed,) studied this question.