Effects of aquaporin-4 on neurovascular coupling and brain network in Alzheimer’s disease mice model

Neurovascular uncoupling can be found in the early stage of AD continuum. The effect of AQP4 content on neurovascular coupling (NVC) in AD mice is unclear. Adult 5xFAD mice and wild-type mice were employed in this study. Mice received TGN-020, an AQP4 inhibitor, intraperitoneally. The results showed that 20 min after the injection of TGN-020, reduced ReHo in the basal area of the frontal lobe, a trend of reduced functional connectivities and disordered network properties were found among the AQP4-inhibited WT and 5xFAD mice. Therefore, Inhibition of AQP4 may reduce the NVC, and disorder the functional network.