August 5, 2024Open Access

Lactate dehydrogenase A (LDHA)-mediated lactate generation promotes pulmonary vascular remodeling in pulmonary hypertension

DWDaiqian WuChengdu Third People's Hospital SWShuo WangKailuan General Hospital FWFengxian WangNanjing Drum Tower Hospital

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Abstract

High levels of lactate are positively associated with prognosis and mortality in pulmonary hypertension (PH). Lactate dehydrogenase A (LDHA) is a key enzyme for the production of lactate. This study is undertaken to investigate the role and molecular mechanisms of lactate and LDHA in PH.

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Wu et al. (Mon,) studied this question.

synapsesocial.com/papers/68e5d588b6db64358756bba3 https://doi.org/https://doi.org/10.1186/s12967-024-05543-7

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