Management of Infected Tibial Nonunion: Combining Synthetic Bone Grafting with Continuous Local Antibiotic Perfusion (CLAP)

Objective:Unusual or unexpected effect of treatment Background:Infection control and reconstruction of bone and soft tissue are essential for treating infected nonunion.Continuous local antibiotic perfusion (CLAP) is a drug delivery system that continuously delivers antibiotics at the required concentration, area, and duration.This case report describes the instance of infected nonunion in which infection eradication and bone union were achieved using CLAP and synthetic bone grafting while retaining the implant. Case Report:The case was a 31-year-old woman with an infected nonunion.After she underwent osteosynthesis using nail for open fractures of tibia and fibula, bone union remained unachieved, and she exhibited skin defects and draining of pus.Following the removal of the infected granulation tissue from the bone defects, 2 bone marrow needles, serving as intramedullary antibiotic perfusion (iMAP) pins, were inserted into the medullary cavity tibia.A double-lumen tube was placed in the subcutaneous pocket as the intra-soft tissue antibiotic perfusion (iSAP) tube.No bone mobility was observed around the bone defect and nail, and replacement of the implant was not necessary.Beta-tricalcium phosphate was transplanted to the bone defect, and negative pressure wound therapy was applied.Gentamicin was injected continuously through iMAP and iSAP.Finally, the infection was eradicated, and cortical bone bridging was observed without additional surgery or adverse effects. Conclusions:CLAP emerges as a viable treatment option for infected nonunion, as it enables the delivery of antibiotics at a concentration sufficient for infection control while providing the surgeon with flexibility to design the area, dosage, and duration of antibiotic delivery.