Designing polysaccharide materials for tissue repair and regeneration

Tissue repair and regeneration are critical processes for maintaining the integrity and function of various organs and tissues. Recently, polysaccharide materials and protein materials have garnered interest for use in tissue repair strategies. However, polysaccharides are more stable and unaffected by temperature and pH changes compared to proteins, and some polysaccharides can provide stronger mechanical support, which is particularly important for constructing tissue-engineered scaffolds and wound dressings. This Review provides an in-depth overview of the origins of polysaccharides, the advantages of polysaccharide materials, and processing and design strategies. In addition, the potential of polysaccharide materials for the restoration of tissues such as skin, heart, and nerves is highlighted. Finally, we discuss in depth the challenges that polysaccharide materials still face in tissue repair, such as the stability of the material, regulating mechanical characteristics and deterioration rates under different conditions. To achieve more effective tissue repair and regeneration, future research must focus on further improving the characteristics and functionalities of polysaccharide materials.