Platelet-rich Plasma as a Treatment Modality for Wound Healing: An Open Randomized Controlled Trial

Unlike conventional management protocols, like dressings, wound debridement, and skin grafting that do not facilitate healing, platelet-rich plasma (PRP) directly feeds growth factors to enhance wound healing. An open randomized controlled trial with a sample size of 60 was carried out on patients with a wound surface area ≤10 × 10 cm2 with 30 participants in each. The PRP group (PRPG) was given autologous PRP using the infiltration technique, and the control group (CG) was treated using conventional dressings. The PRPG showed a reduction from 1421 to 661 mm2, whereas the CG showed a decrease from 1710 to 1478 mm2 on day 30. The PRP group had a decreased hospital stay (n = 14) in comparison to the CG (n = 17.5 days). The rate of epithelization (mean) is 11.12 mm2/day in the CG and 34.026 mm2/day in the PRPG. Platelet-rich plasma (PRP) can be considered a primary modality for wound management because of decreased length of hospital stay, analgesic effects, fastened rate of healing, and absence of adverse reactions.