Differences Between Glycated Hemoglobin and Glucose Management Indicator in Real-Time and Intermittent Scanning Continuous Glucose Monitoring in Adults With Type 1 Diabetes

Background: This study demonstrates the difference between glucose management indicator (GMI) and glycated hemoglobin (HbA 1c ) according to sensor mean glucose and HbA 1c status using 2 continuous glucose monitoring (CGM) sensors in people with type 1 diabetes. Methods: A total of 275 subjects (117 Dexcom G6 G6 and 158 FreeStyle Libre 1 FL) with type 1 diabetes was included. The G6 and FL sensors were used, respectively, over 90 days to analyze 682 and 515 glycemic profiles that coincide with HbA 1c . Results: The mean HbA 1c was 6.6% in Dexcom G6 and 7.2% in FL profiles. In G6 profiles, GMI was significantly higher than HbA 1c irrespective of mean glucose (all P 0.5% improved from 60.1% to 30.9% when using the revised GMI equation in G6 profiles. In FL profile, the overall mean difference between GMI and HbA 1c was 0 ( P = .966). The GMI was significantly lower by 0.9% than HbA 1c of 9.0% to 9.9% and higher by 0.5% in HbA 1c of 5.0% to 5.9% (all P < .001). Conclusions: The GMI is overestimated in G6 users, particularly those with well-controlled diabetes, but the GMI and HbA 1c discordance improved with a revised equation from the observed data. The FL profile showed greater discordance for lower HbA 1c levels or higher HbA 1c levels.