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G1/S transition of the cell cycle. Overexpression of cyclin D1 in oral squamous cell carcinoma isassociated with poor prognosis and resistance to cisplatin-based conventional chemotherapy.Objectives:To assess the immunohistochemical expression of cyclin D1 in different grades of oralsquamous cell carcinoma (OSCC) and to determine the association of cyclin D1 expression withhistopathological grades, age, gender, anatomic site, and the habit of using tobacco, betel quid andareca nut of OSCC patients.Methods: This cross-sectional observational study was conducted at the Department of Pathology,Sylhet MAG Osmani Medical College, Sylhet during the study period (from March, 2019 to April,2020 and July, 2021 to April, 2022). A total of 52 small biopsy cases were processed; paraffinblocks were made and stained with routine H&E stain. The sections were examinedmicroscopically and the tumors were graded histologically. Immunohistochemistry was performedby using a commercially available anti-cyclin D1 antibody. Cyclin D1 overexpression wasconsidered when more than 10% of tumor cells displayed nuclear staining with moderate to strongintensity.Results: Cyclin D1 overexpression was seen in 60% of cases of OSCC. The highest expressionwas seen in moderately differentiated followed by poorly differentiated and well-differentiatedsquamous cell carcinoma, with no statistically significant correlation. It did not correlate with age,gender, anatomic site, the habit of using tobacco, betel quid, and areca nut chewing.Conclusion: In Bangladesh, 60% of cases of OSCC showed cyclin D1 overexpression which wasquite similar to the findings of other countries. Further, alarge cohort study on resected samples canbe done for overall survival and future targeted therapy against cyclin D1.
AS et al. (Thu,) studied this question.