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Pharmaceutical research is always looking for novel ways to distribute drugs and developing these methods to increase the effectiveness of existing medications. The physicochemical characteristics of the drug determine the dose form. Lipophilic API development is a result of recent discoveries in high-throughput screening. A topical broad-spectrum antifungal agent is luliconazole. Due to its lower water solubility, topical administration is limited, and topical absorption is confined. The stratum corneum’s lipid phase’s solubility of the medication also serves as a rate-limiting step for penetration. Because fungal infections impact the skin’s epidermis, dermis, and deeper layers, medicine administration must be tailored to target high drug concentrations at the layers of the epidermis and dermis
Saish et al. (Tue,) studied this question.