871-P: One-Year Real-World Evidence of Effectiveness of Carbohydrate Restricted Nutrition Therapy in Adults with Type 2 Diabetes across Age and Gender

Type 2 diabetes (T2D) affects 12% of US adults, with a growing presence in young adults. Virta Health provides carbohydrate restricted nutrition therapy (CRNT) through continuous remote care (CRC) to US adults with T2D, but the impact of the program across age and gender groups is unknown. This retrospective real-world study assessed differences in health marker change over one year between age groups, and secondarily between genders, with linear mixed effects models. One year retention was high across age groups (64%, 76%, 76%; ages 18-44, 45-64, 65+) and gender (76% male, 73% female), and a random sample (N=750) of patients enrolled one year was selected for this analysis. Broadly, all age groups and both genders improve over time in multiple health markers (weight, A1c, triglycerides, HDLc, liver enzymes) with no change in Total Cholesterol or LDLc, and with few differences between groups. Mean A1c in all age groups and both genders is 7% at one year. These results provide real-world evidence that CRNT favorably impacts glycemic control, cardiometabolic health, and hepatic function in adults with T2D across age groups and in both men and women. The A1c reduction in the youngest age group is notable, as early glycemic control may confer legacy effects on complication rates for many decades. Disclosure C.G.P. Roberts: Other Relationship; Virta Health Corp. R.N. Adams: Employee; Virta Health Corp. Stock/Shareholder; Virta Health Corp. S.J. Athinarayanan: Employee; Virta Health Corp. B.M. Volk: Employee; Virta Health Corp. Stock/Shareholder; Virta Health Corp. A.R. Zoller: Employee; Virta Health Corp. Stock/Shareholder; Virta Health Corp. A.L. McKenzie: Employee; Virta Health Corp. Stock/Shareholder; Virta Health Corp. Employee; Abbott.