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Abstract Backgrounds and Aims The Mayo endoscopic subscore MES is the most popular endoscopic disease activity measure of ulcerative colitis UC. Artificial intelligence AI-assisted colonoscopy is expected to reduce diagnostic variability among endoscopists. However, no study has been conducted to ascertain whether AI-based MES assignments can help predict clinical relapse, nor has AI been verified to improve the diagnostic performance of non-specialists. Methods This open-label, prospective cohort study enrolled 110 patients with UC in clinical remission. The AI algorithm was developed using 74 713 images from 898 patients who underwent colonoscopy at three centres. Patients were followed up after colonoscopy for 12 months, and clinical relapse was defined as a partial Mayo score 2. A multi-video, multi-reader analysis involving 124 videos was conducted to determine whether the AI system reduced the diagnostic variability among six non-specialists. Results The clinical relapse rate for patients with AI-based MES = 1 (24.5% 12/49) was significantly higher log-rank test, p = 0.01 than that for patients with AI-based MES = 0 (3.2% 1/31). Relapse occurred during the 12-month follow-up period in 16.2% 13/80 of patients with AI-based MES = 0 or 1 and 50.0% 10/20 of those with AI-based MES = 2 or 3 log-rank test, p = 0.03. Using AI resulted in better inter- and intra-observer reproducibility than endoscopists alone. Conclusions Colonoscopy using the AI-based MES system can stratify the risk of clinical relapse in patients with UC and improve the diagnostic performance of non-specialists.
Ogata et al. (Mon,) studied this question.