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Abstract Purpose Currently, taxane-based cytotoxic anticancer drugs are the drug of choice for chemotherapy in various carcinomas. However, they can induce chemotherapy-induced peripheral neuropathy (CIPN), which often has a significant impact on quality of life. Currently, only duloxetine is recommended for the relief of CIPN pain, but it does not provide significant improvement and it is important to prevent the onset of CIPN. There are few reports of preventive effects on chemotherapy for lung cancer and little is known about the combination of compression and cooling therapies. Methods At our institution, we have conducted a study in patients with advanced lung cancer on a taxane-containing regimen, using a combination of compression therapy and cooling therapy, to determine the preventive effect on CIPN. Results The results showed a reduction in the incidence of CIPN in the group treated with combination therapy compared with previous reports, while ensuring safety. Conclusion We believe that the combination of compression and cooling therapy may be useful in the prevention of CIPN.
Nakajima et al. (Tue,) studied this question.
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