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Pituitary neuroendocrine tumor (PitNET)/adenoma classification is controversial as the majority of pituitary tumors follow an indolent course. The use of immunohistochemistry (IHC) allows for classification according to lineage-specific transcription factors (TF), cytoplasmic granule density and proliferation index to help identify more aggressive tumors and characterize their hormone expression. We present a rare case of a patient with a plurihormonal PitNET.
Ford et al. (Wed,) studied this question.